Objective : This study was undertaken to determine if Plantaginis Semen Aquacupuncture(PSA) has a protective effect against CCI_4 induced Hepatoxicity in Rats.
Methods : The experimental group were divided into Normal group(untreated group), Control group, PSA group. Rats were administered orally CCI_4(0.1ml/㎏) for 4 days. In experiments for PSA effect, rats received 0.1 ml of PSA extraction in both sides of corresponding Ga￣nshu￣(BL18) of human body for 3 days after treated CCI_4. Variation of weight and biochemical assays(GOT, GPT, LDH, ALP, total cholesterol, triglyceride, albumin) were performed.
Results : In Control group, CCI_4 increased serum GOT, GPT, LDH, ALP and albumin and decreased weight, total cholesterol and triglyceride. PSA significantly decreased serum GOT, GPT, LDH and increased total cholesterol as compared with Control group.
Conclusion : These results indicate that PSA could be used in prevention and treatment of hepatoxicity. However, precise mechanisms of PSA protection remain to be determined.
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